Children (including neonates and older children) are at increased risk of developing hyponatremia as well as for developing hyponatremic encephalopathy [see Warnings and Precautions (5.4)]. Children 2 years of age and olderUse and dose must be determined by your doctor. Dextrose 50% Abboject , Ansyr Syringe Contraindications Available for Android and iOS devices. Report an adverse event or concern about the quality of a Pfizer product, Assistance programs (for eligible patients). Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. In severe cases or in older infants, higher or repeated single doses up to a maximum 1012 mL of 25% dextrose injection may be required. Administer hypertonic dextrose solutions slowly. Dextrose injection without electrolytes should not be administered simultaneously with blood through the same infusion set because of the possibility that pseudoagglutination of red cells may occur. You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at. NOTE: This solution is hypertonic - See WARNINGS and PRECAUTIONS. Minor/Significance Unknown. Dextrose, USP is chemically designated C6H12O6 H2O (D-glucose monohydrate), a hexose sugar freely soluble in water. In order to provide you with relevant and meaningful content we need to know more about you. Administer orally as a gel or a chewable tablet for the management of acute symptomatic hypoglycemia in conscious patients who are able to swallow. Slow infusion of hypertonic solutions is essential to insure proper utilization of dextrose and avoid production of hyperglycemia. When smaller doses are required, the unused portion should be discarded with the entire unit. View explanations for tiers and LifeShield is the trademark of ICU Medical, Inc. and is used under license. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZGV4dHJvc2UtYW50aWRvdGUtMzQzNzIz. Increase the infusion rate gradually as indicated by frequent monitoring of blood glucose concentrations [see Warnings and Precautions (5.1), Use in Specific Populations (8.4)]. /Type /Pages LifeShield Abboject Syringe Fliptop Container. Dextrose is also often used to preserve packaged foods and extend their shelf life because its not as sweet as other sugars, such as sucrose., Other foods that commonly have dextrose include:, Because dextrose is very similar to glucose, its quickly digested and replenishes energy in a short time. This third-party website is neither owned nor controlled by Pfizer, and Pfizer does not endorse and is not responsible for the content or services of this site. /T1_0 16 0 R The solution contains no bacteriostat, antimicrobial agent or added buffer (except for pH adjustment) and is intended only for use as a single-dose injection. (6). Close clinical monitoring may be warranted. See WARNINGS 5% Dextrose Injection, USP solution is sterile and nonpyrogenic. When a concentrated dextrose infusion is abruptly withdrawn, it is advisable to follow with the administration of 5% or 10% dextrose injection to avoid rebound hypoglycemia. The choice of dextrose concentration, rate and volume depends on the age, weight, clinical and metabolic conditions of the patient and concomitant therapy. (See Prescribing Limits under Dosage and Administration.). Fever, injection site infection, extravasation. /GS0 19 0 R Properly discard this product when it is expired or no longer needed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. See WARNINGS and 50% Dextrose Injection, USP is a sterile, nonpyrogenic, hypertonic solution of dextrose in water for injection for intravenous injection as a fluid and nutrient replenisher. 1025% dextrose injections used in neonates and infants to restore blood glucose concentrations in the treatment of acute symptomatic hypoglycemia. In the event of overdosage (hyperglycemia) during therapy, re-evaluate the patient and institute appropriate corrective measures. Dextrose has a high glycemic index, which means that it increases blood sugar levels quickly and is a good source of energy., Dextrose is often used as a sweetener in baked products because it helps them brown more easily. Average normal adult requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). /Version /1.4 American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. Dextrose Monograph for Professionals - Drugs.com stream For central venous administration: 2.5% Dextrose and 0.45% Sodium Chloride Injection, 3.3% Dextrose and 0.30% Sodium Chloride Injection, 5% Dextrose and 0.11% Sodium Chloride Injection, 5% Dextrose and 0.2% Sodium Chloride Injection, 5% Dextrose and 0.225% Sodium Chloride Injection, 5% Dextrose and 0.3% Sodium Chloride Injection, 5% Dextrose and 0.33% Sodium Chloride Injection, 5% Dextrose and 0.45% Sodium Chloride Injection, 5% Dextrose and 0.9% Sodium Chloride Injection, 10% Dextrose and 0.2% Sodium Chloride Injection, 10% Dextrose and 0.45% Sodium Chloride Injection, 10% Dextrose and 0.9% Sodium Chloride Injection. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. % Insulin resistance causes feelings of tiredness and increases the risk of many diseases.. WebCONTRAINDICATIONS. endobj If possible before you receive this medicine, tell your doctor if you have ever had: 1. diabetes (unless you are using dextrose to VA class: TN100. When administered intravenously, this solution provides a source of water and carbohydrate. 50% Dextrose Injection is hypertonic and may cause phlebitis and thrombosis at the site of injection. 25-50 g (50-100 mL of D50W solution); administer with thiamine (50-100 mg IV) to prevent Wernicke's encephalitis, 10-25 g (40-100 mL of D25W solution or 20-50 mL of D50W solution) IV; may require repeated boluses, 400-600 mg of glucose/kg/hr needed for most insulin overdoses, Alternatively, administer 25-50 g (D50W) IV; may repeat doses in severe cases; determine glucose levels before injecting dose; in emergencies, may administer promptly before obtaining glucose results, 25-50 g (250-500 mL D10W) plus 10 units regular insulin IV over 30-60 min, < 6 months: 250-500 mg/kg/dose (1-2 mL/kg/dose D25W), > 6 months: 0.5-1g/kg/dose (2-4 mL/kg/dose D25W). /GS1 20 0 R Store at 20 to 25C (68 to 77F). /Count 2 Clinical studies of 10% Dextrose Injection did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Carcinogenesis, Mutagenesis, Impairment of FertilityStudies with solutions in polypropylene syringes have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility. The primary complication of peripheral access is venous thrombophlebitis, which manifests as pain, erythema, tenderness or a palpable cord. What Happens if You Eat Dextrose? Positive and Negative Although not all of these side effects may occur, if they do occur they may need medical attention. Subsequently, if required, administer 10% dextrose injection by continuous IV infusion to stabilize blood glucose concentrations. Not known whether dextrose is distributed into human milk. (See Electrolyte Disturbances under Cautions.). Risk of solute overload and resultant congestive conditions with peripheral and/or pulmonary edema is directly proportional to the electrolyte concentration administered. Links to sites outside of Pfizer Medical Information are provided as a resource to the viewer. The solution should be given slowly, preferably through a small bore needle into a large vein, to minimize venous irritation. Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. In the event of overhydration or solute overload during therapy, re-evaluate the patient and institute appropriate corrective measures. Drug information provided by: Merative, Micromedex. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. dextrose (Antidote) decreases levels of magnesium chloride by increasing renal clearance. Excess consumption of dextrose can also worsen depression, as well as acne and other skin conditions. Medically reviewed by Drugs.com. Please choose the category that best describes you. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. When administered intravenously this solution restores blood glucose levels in hypoglycemia and provides a source of carbohydrate calories. For that reason, it can be quickly used as a source of energy by the human body. [See USP Controlled Room Temperature Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine. No specific dosage recommendations for special populations. Injection of the solution should be made slowly. Administer hypertonic dextrose solutions (e.g., >5%) slowly; rapid administration may produce substantial hyperglycemia and hyperosmolar syndrome. The container does not require entry of external air during administration. Last updated on Feb 1, 2022. << Dextrose and sodium chloride are also commercially available in combination with electrolytes and potassium chloride for IV administration. Risk of hyperglycemia and/or hyperosmolar syndrome (e.g., dehydration, hypovolemia, mental confusion, loss of consciousness) with rapid administration, especially in patients with chronic uremia and known carbohydrate intolerance. Mechanism : This medication is an intravenous (IV) solution used to supply fluids and calories to the body. /Contents 23 0 R The product information provided by this site is intended only for health care professionals, patients, consumers and caregivers in the United States. /StructParents 1 Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. The amount of water that can permeate from the container into the overwrap is insufficient to affect the solution significantly. 1,000mL10% Dextrose Injection, USP100 grams per 1,000 mL (100 mg per mL)For intravenous use. Links to sites outside of Pfizer Medical Information are provided as a resource to the viewer. /XObject << Dextrose injection undergoes oxidation to carbon dioxide and water. Chewable tablet: 15 g (3 tablets). 50% dextrose injections used in adults and children to restore blood glucose concentrations in the treatment of hypoglycemia resulting from insulin excess or other causes. Dextrose is used in a wide range of products because it has several useful properties and is widely available. Available for Android and iOS devices. The solution contains no bacteriostatic, antimicrobial agent or added buffer and is intended only for use as a single-dose injection. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Your doctor will check your progress closely while you are receiving this medicine. If thrombosis should occur during administration, the injection should be stopped and corrective measures instituted. /Pages 2 0 R dextrose (Antidote) decreases levels of magnesium hydroxide by increasing renal clearance. Follow the instructions on the medicine label if you are using this medicine without a prescription. Use Caution/Monitor. Hyperglycemia is associated with an increase in serum osmolality, resulting in osmotic diuresis, dehydration and electrolyte losses [see Warnings and Precautions (5.5)]. /Kids [3 0 R 4 0 R] HTMo0W2>DO E5 !QQv8AEEGll"SmwUxo)hbJKx>K\6.|p]y_v15 'X-0Na3X],_4H]`D>aj!7]R$;dcmV/4N;i+3: 5 tc2H)d#q]Yi`F} `F2 .hD*&jK0*AOE7IWji\q(H,F?L'aQ(rlC3~7) X]j`ild+Y G9kS"X`u8r[kYnxDH t Z$AO^AU&Y;"&. /BleedBox [12.0 12.0 642.0 822.0] Generic name: dextrose monohydrate /Resources << Adults15 grams (1 tube) as needed. If over-exposure occurs, call your Poison Control Center at 1-800-222-1222 for current information on the management of poisoning or overdosage. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. commonly, these are generic drugs. Cautions for Dextrose Contraindications. /Fm1 24 0 R The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. UnconsciousnessShould not be used in patients with these conditions. /GS0 19 0 R The maximum rate of dextrose administration which does not result in glycosuria is the same as cited above. For total parenteral nutrition 50% Dextrose Injection, USP is administered by slow intravenous infusion (a) after admixture with amino acid solutions via an indwelling catheter with the tip positioned in a large central vein, preferably the superior vena cava, or (b) after dilution with sterile water for injection. Dextrose ( antidote) is used for acute alcohol SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Concentrated dextrose solutions should not be administered subcutaneously or intramuscularly. Additives may be incompatible. Significant hyperglycemia and possible hyperosmolar syndrome may result from too rapid administration Hyperosmolar syndrome, resulting from excessively rapid administration of concentrated dextrose may cause mental confusion and/or loss of consciousness. 1 0 obj Minor/Significance Unknown. 50% Dextrose Injection is hypertonic and may cause phlebitis and thrombosis at the site of injection. It can also cause symptoms such as frequent urination, thirst, nausea and vomiting, shortness of breath, and stomach pain when eaten in excess. Remove the catheter as soon as possible, if thrombophlebitis develops. Because many drugs are excreted in human milk, caution should be exercised when 50% Dextrose Injection, USP is administered to a nursing mother. It is also not known whether dextrose can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Solutions containing dextrose should be used with caution in patients with known subclinical or overt diabetes mellitus. Hyperglycemia or Hyperosmolar Hyperglycemic State, Other Products that Affect Glycemic Control, Vasopressin or Fluid and/or Electrolyte Balance, Table 1. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly by visiting www.fda.gov/medwatch or by calling (800)-332-1088. << A specimen for blood glucose determination should be taken before injecting the dextrose. If no response within 15 minutes, take again another dose. (2) Dextrose injection should not be (, 10% (0.1 grams/mL): 10 grams of dextrose hydrous per 100 mL in flexible plastic containers: 250 mL, 500 mL, and 1000 mL, Hyperglycemia and hyperosmolar hyperglycemic state, Hyponatremia and hyponatremic encephalopathy, Electrolyte imbalance, fluid overload and hypervolemia, Hyperglycemia and hyperosmolar hyperglycemic state. Contraindications Warnings and Precautions Adverse Reactions/Side Effects Drug Interactions Use In Specific Populations Overdosage Description Clinical Dextrose is oxidized to carbon dioxide and water, yielding energy. Your kidneys filter sugars out of your urine. Adding plans allows you to compare formulary status to other drugs in the same class. Significant hyperglycemia and possible hyperosmolar syndrome may result from too rapid administration. We comply with the HONcode standard for trustworthy health information. The products discussed herein may have different product labeling in different countries. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine only as directed by your doctor. WARNING: Do not use flexible container in series connections. Concentrated dextrose solutions (e.g., 10, 20, 30, 40, 50, and 70%) contain aluminum; may reach toxic levels with prolonged parenteral administration if kidney function is impaired, including in premature neonates. Weight gain. /ExtGState << All rights reserved. provider for the most current information. Dextrose is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Maximum infusion rate without producing glycosuria: 0.5 g/kg per hour. Depending on the volume and rate of infusion, the patient's underlying clinical condition and capability to metabolize dextrose, intravenous administration of 10% Dextrose Injection can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, (including hypoosmotic hyponatremia), overhydration, congested states or pulmonary edema. Care should be exercised to insure that the needle is well within the lumen of the vein and that extravasation does not occur. Discard unused portion. Stop infusion immediately and treat patient accordingly if signs or symptoms of a hypersensitivity reaction develop. Children 2 This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Dextrose: Generic, Uses, Side Effects, Dosages, Interactions It is preferable to administer hypertonic dextrose solutions via an IV catheter placed into a large central vein, and only after appropriate admixture or dilution. PregnancyAnimal reproduction studies have not been conducted with dextrose. If you log out, you will be required to enter your username and password the next time you visit. If possible, alternate the injection site daily. free Minor (1)dextrose (Antidote) decreases levels of magnesium sulfate by increasing renal clearance. Administer orally, by slow IV injection, or slow IV infusion. Calculate dosage based on age, weight, clinical condition, fluid and electrolyte balance, and acid-base balance of the patient. If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations in the solution. Other Products that Affect Glycemic Control, Vasopressin or Fluid and/or Electrolyte Balance: Monitor blood glucose concentrations, fluid balance, serum electrolyte concentrations and acid-base balance. Appropriate therapeutic countermeasures must be instituted as clinically indicated. /Fm1 14 0 R Dextrose, USP is chemically designated D-glucose, monohydrate (C6H12O6 H2O), a hexose sugar freely soluble in water. Following oral tablet administration of a 20-g dose of dextrose in hypoglycemic patients, mean blood glucose concentration increased by 32 mg/dL 20 minutes after administration. If such patients receive parenteral aluminum in amounts >45 mcg/kg daily, aluminum may accumulate at levels associated with CNS and bone toxicity. If no response within 15 minutes, take again another dose. Risk of glucose intolerance and hyperglycemia in pediatric patients, especially in low-birthweight infants and neonates. If you cannot use the above website to report an adverse event related to a Pfizer product, please call Pfizer Medical Information at (800) 438-1985. Eating too much dextrose can increase your risk of heart disease. (See IV Administration under Dosage and Administration.) The risks associated with eating dextrose are the same as those of any sugars. >> Dextrose: Side Effects, Dosage & Uses - Drugs.com If use cannot be avoided, monitor serum sodium concentrations. It has the following structural formula: Water for Injection, USP is chemically designated H2O. Dextrose - Mechanism, Indication, Contraindications, All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Not known whether dextrose is excreted into milk. 500mL10% Dextrose Injection, USP50 grams per 500 mL (100 mg per mL)For intravenous use. flex For peripheral vein administration: The administration rate should be governed, especially for premature infants with low birth weight, during the first few days of therapy, by the patient's tolerance to dextrose. << /ExtGState << dichlorphenamide and dextrose (Antidote) both decrease serum potassium. Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com. The solution has an osmolarity of 2.53 mOsmol/mL (calc. /StructParents 0 The risk of dilutional states is inversely proportional to the electrolyte concentrations in the administered solution. /Parent 2 0 R /CropBox [0.0 0.0 654.0 834.0] puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. Intravenous solutions containing dextrose are indicated for parenteral replenishment of fluid and minimal carbohydrate calories as required by the clinical condition of the patient. It undergoes rigorous internal medical review and is updated regularly to reflect new information. This medicine is to be used only when needed. Carbohydrate in the form of dextrose may aid in minimizing 25% Dextrose Injection, USP is supplied in single-dose containers as follows: CONCENTRATED DEXTROSE FOR INTRAVENOUS ADMINISTRATION Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine. Correct fluid and electrolyte imbalances and provide essential vitamins and minerals, if necessary. Information last revised July 2016. Abboject is a trademark of the Abbott group of companies. A concentrated dextrose solution should not be used when intracranial or intraspinal hemorrhage is present, nor in the presence of delirium tremens if the patient is already dehydrated. Dextrose injection without electrolytes should not be administered simultaneously with blood through the same infusion set because of the possibility that pseudoagglutination of red cells may occur. >> Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Additional monitoring is recommended for patients with water and electrolyte disturbances that could be aggravated by increased glucose, insulin administration and/or free water load. /Rotate 0 Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. %PDF-1.4 Access your plan list on any device mobile or desktop. The product information provided by this site is intended only for health care professionals, patients, consumers and caregivers in the United States. To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Electrolyte deficits, particularly in serum potassium and phosphate, may occur during prolonged use of concentrated dextrose solutions. Dosage should be adjusted to meet individual patient requirements. /Type /Catalog 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Patients with substantial electrolyte losses (e.g., resulting from protracted nasogastric suctioning, vomiting, diarrhea, or GI fistula drainage) may require additional electrolyte supplementation. Use caution in DM or carbohydrate intolerance. Twist tip off and squeeze entire contents of the tube into mouth and swallow. This drug is available at the lowest co-pay. Data sources include IBM Watson Micromedex (updated 1 Aug 2023), Cerner Multum (updated 20 Aug 2023), ASHP (updated 10 Aug 2023) and others. Children: Maximum infusion rate without producing glycosuria: 0.5 g/kg per hour. << Possible hypokalemia and hypophosphatemia after prolonged use of concentrated dextrose solutions. Repeat dose after 1020 minutes, if necessary. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. You may report side effects to the FDA at 1-800-FDA-1088. /ColorSpace << If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly by visiting www.fda.gov/medwatch or by calling (800)-332-1088.
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